High-grade evidence to support the routine use of sperm DNA fragmentation testing as part of initial screening investigations for infertility is lacking. Sperm DNA fragmentation tests are poor at predicting outcomes in patients undergoing assisted reproductive technologies, particularly for patients undergoing IVF or intracytoplasmic sperm injection (ICSI), and should not be used to guide treatment decision-making. For more information:
Agarwal A, et al. Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios. Transl Androl Urol 2016;5:935-50. PMID: 28078226.
Cissen M, et al. Measuring sperm DNA fragmentation and clinical outcomes of medically assisted reproduction: a systematic review and meta-analysis. PLoS One. 2016;11(11):e0165125. PMID: 27832085.
Pfeifer S, et al. The clinical utility of sperm DNA integrity testing: a guideline. Fertil Steril. 2013;99(3):673–7. PMID: 23391408.
Zhang Z, et al. Sperm DNA fragmentation index and pregnancy outcome after IVF or ICSI: a meta-analysis. J Assist Reprod Genet. 2015;32:17–26. PMID: 25392073.