Antimicrobials such as fluoroquinolones, trimethoprim-sulfamethoxazole, clindamycin, linezolid, metronidazole and fluconazole have excellent bioavailability and only rarely need to be administered intravenously. Use of oral formulations of these medications reduces the need for placement and maintenance of venous access devices and their associated complications.
Sources:
Centers for Disease Control and Prevention. Core elements of antimicrobial stewardship programs [Internet]. Atlanta, GA: US Department of Health and Human Resources, CDA; 2014 [cited 2015 Jul 10].
Dellit TH, et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis. 2007 Jan 15;44(2):159-77. PMID: 17173212.
Li HK, et al. Oral versus Intravenous Antibiotics for Bone and Joint Infection. N Engl J Med 2019; 380: 425-36. PMID: 30699315.