Topical corticosteroid/antifungal products in cream or ointment formulations contain high-potency corticosteroids generally considered inappropriate for skin conditions affecting the face and skin folds. These have been prescribed for suspected superficial fungal infections and diaper dermatitis. However, evidence demonstrates inferior clinical efficacy, higher recurrence rates and harmful side effects (skin thinning and systemic absorption) compared to topical antifungals alone. In practice, their use may complicate diagnosis and prolong treatment. Suspicion of fungal infection should be confirmed by skin scraping, and fungal infections with substantial itch may be treated with a short-term topical mild to moderate corticosteroid prescription. For more information:
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Wheat CM, et al. Current trends in the use of two combination antifungal/corticosteroid creams. Pediatrics. 2017 Jul;186:192-195. PMID: 28438376.