Reverse Transcription-Polymerase Chain Reaction (RT-PCR) amplification tests remain positive in some people’s respiratory samples after recovery from coronavirus disease 2019 (COVID-19) infection with prolonged viral RNA shedding demonstrated without direct evidence of there being viable virus capable of replicating or causing infection. Test-based strategies relying on the absence of viral fragments, such as RNA or antigen, for return to work clearance may therefore inappropriately delay return to work. The United States Centres for Disease Control (US-CDC) recommends time-based approaches. A time-based approach based on epidemiologic studies suggests that it is safe to return to work 10 to 20 days after symptom onset depending on the severity of the illness and symptom resolution criteria. Return to work criteria requiring one or more negative RT-PCR or other approved tests may still be considered in high risk occupational settings such as working with high risk persons in a health care setting. For more information:
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